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T-2 toxin is hydroxylated by chicken cyp3a37

WebOur results showed that chicken CYP3A37 is able to convert T-2 to 3′-OH T-2 with an apparent K m of 15.29 μM, and T-2 hydroxylation activity of CYP3A37 is strongly inhibited by ketoconazole (IC 50 = 0.11 μM). We also observed that chicken CYP3A37 can catalyze erythromycin N-demethylation, another CYP3A-specific activity. WebSep 30, 2013 · Our results showed that chicken CYP3A37 is able to convert T-2 to 3'-OH T-2 with an apparent Km of 15.29 μM, and T-2 hydroxylation activity of CYP3A37 is strongly …

T-2 mycotoxin: toxicological effects and decontamination strategies

WebDec 1, 2024 · Download Citation Activated FXR promotes xenobiotic metabolism of T-2 toxin and attenuates oxidative stress in broiler chicken liver The transmission of T-2 toxin and its metabolites into the ... WebJan 29, 2024 · T-2 toxin is type A trichothecenes mycotoxin, which produced by fusarium species in cereal grains. T-2 toxin has been shown to induce a series of toxic effects on the health of human and animal, such as immunosuppression and carcinogenesis. Previous study has proven that T-2 toxin caused hepatotoxic … marylbombshell https://bneuh.net

An update on T-2 toxin and its modified forms: metabolism ...

WebMay 1, 1985 · Identification of various T-2 toxin metabolites in chicken excreta and tissues. ... T-2 toxin is hydroxylated by chicken CYP3A37. Yuan Y, Zhou X, Yang J, Li M, Qiu X. Food Chem Toxicol, 62:622-627, 30 Sep 2013 Cited by: 11 articles PMID: 24090734. Chicken cytochrome P450 1A5 is the key enzyme for metabolizing T-2 toxin to 3'OH-T-2. ... WebAlthough T-2 toxin occurs naturally in cereal grains, contamination with T-2 toxin is less frequent than with deoxynivalenol (DON). However, T-2 toxin (LD50 in mice: 2–4 mg kg … husky tough storage bin

Yiyang YUAN assistant research fellow PhD Chinese Academy …

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T-2 toxin is hydroxylated by chicken cyp3a37

T-2 toxin is hydroxylated by chicken CYP3A37.

WebAlthough T-2 toxin occurs naturally in cereal grains, contamination with T-2 toxin is less frequent than with deoxynivalenol (DON). However, T-2 toxin (LD50 in mice: 2–4 mg kg … WebMar 6, 2024 · Yuan Y, Zhou X, Yang J, Li M, Qiu X (2013) T-2 toxin is hydroxylated by chicken CYP3A37. Food Chem Toxicol 62:622–627. CAS Google Scholar Yun Y, Gao T, Li Y, Gao Z, Duan J, Yin H, Duan W (2016) Excretory function of intestinal tract enhanced in kidney impaired rats caused by adenine. Sci World J 16:2695718

T-2 toxin is hydroxylated by chicken cyp3a37

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WebSep 30, 2013 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J WebA single nucleotide polymorphism in the 11th intron was used to assign CYP3A37 to turkey linkage group 10 (corresponding to chicken chromosome 14, GGA14). Because of the important role of P450s in the extreme sensitivity of turkeys to the toxic effects of AFB(1), this study will contribute to the identifying allelic variants of this important ...

WebDec 1, 2014 · The excellent detection sensitivity in various matrices of T-2 toxin (T-2), which has cytotoxic and immunosuppressive effects in DNA and RNA synthesis, is a highly desirable characteristic. A... WebT-2 toxin is hydroxylated by chicken CYP3A37 [2013] Yuan, Yiyang; Zhou, Xiaojie; Yang, Jiannan; Li, Mei; et al. Access the full text

WebOct 1, 2024 · T-2 toxin is a secondary metabolite produced by the Fusarium genus and is highly toxic to both farmed animals and humans. In our previous study, we found that chicken cytochrome P450 1A5 (CYP1A5) can be significantly induced by T-2 toxin in chicken primary hepatocytes and catalyze T-2 toxin into a more toxic product, 3′-OH-T-2. WebT-2 toxin is hydroxylated by chicken CYP3A37. scientific article published on 30 September 2013. Statements. instance of. scholarly article. 1 reference. stated in. Europe PubMed Central. PubMed ID. 24090734. retrieved.

WebDec 1, 2013 · T-2 toxin (T-2) is an acute toxic trichothecene mycotoxin produced mainly by Fusarium species, detected in many crops including oats, wheat and barley, in animal feed …

WebMay 23, 2013 · T-2 toxin is a naturally occurring contaminant of agricultural commodities. It has been shown that the average T-2 toxin contamination in chicken feed ranges between 0.03 and 0.155 mg/kg [ 23 – 26 ]. The concentration of T-2 toxin used (0.1 μg/mL) in this study is just located at this range. 3.2. husky tower calgaryWebT-2 toxin is hydroxylated by chicken CYP3A37 Author: Yuan, Yiyang, Zhou, Xiaojie, Yang, Jiannan, Li, Mei, Qiu, Xinghui Source: Food and chemical toxicology 2013 v.62 pp. 622 … mary l blood library vermontWebT-2 toxin is hydroxylated by chicken CYP3A37 [2013] Yuan, Yiyang; Zhou, Xiaojie; Yang, Jiannan; Li, Mei; et al. Access the full text husky tower restaurantWebPreliminary metabolic studies of carp reveal that ester hydrolysis of T-2 toxin in carp may not play as important a role as is the case with land animals. 45 Highly Influenced View 1 … mary l boas pdfWebT-2 toxin (T-2) is an acute toxic trichothecene mycotoxin produced mainly by Fusarium species, detected in many crops including oats, wheat and barley, in animal feed and food. It is important to know the metabolic pathway and kinetics of T-2 in food animals given that T-2 can cause serious adverse effects on human health. In this study, we investigated the … mary l byfordWebT-2 toxin is hydroxylated by chicken CYP3A37. @article{Yuan2013T2TI, title={T-2 toxin is hydroxylated by chicken CYP3A37.}, author={Yiyang Yuan and Xiaojie Zhou and Jiannan … husky towing 33039WebJan 21, 2016 · T-2 upregulates the expression of CYP1A4 and CYP1A5 in chicken and CYP3A22, CYP3A29 and CYP3A46 in pigs; and these P450 isoforms have been confirmed as the main enzymes for T-2 hydroxylation in vitro. 42, 89–93 T-2 is a CYP1A1 inducer by activating AhR expression in the human intestinal epithelial cell line Caca-2. 94 Recently, … mary l brechon