WebNov 22, 2024 · SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis. Histopathology. 2008;53:389–402. WebApr 25, 2024 · SH2 containing protein tyrosine phosphatase-2 (SHP2) is a druggable oncogenic phosphatase that is a key shared node in both tumor cells and immune cells. How tumor-cell autonomous SHP2 manages its signaling inputs and outputs to facilitate the growth of tumor cells, drug resistance, immunosuppression, and the limited response of …
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WebAug 14, 2024 · First of all, PHPS1 is a selective Shp2 inhibitor with K i s of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively. Interestingly, PHPS1 with 30 μM for 6 days inhibits the proliferation of human tumor cells. Importantly, PHPS1 results in a reduction in cell numbers of between 0% (Caki-1) to 74% … WebJul 30, 2024 · PTPN11/SHP2, a non-receptor protein tyrosine phosphatase is a prominent target of the receptor tyrosine kinase that participates in positive feedback signalling of the human epidermal growth factor receptors and helps in growth and migration. PTPN11/SHP2 is widely believed to be an oncoprotein, although it’s possible tumor-suppressor role is …
WebJul 30, 2024 · PTPN11/SHP2 using MCF10A, a normal breast epithelial cell line. Knock-down of PTPN11/SHP2 resulted in increased cell migration, cell shape changes to mesenchymal morphology, and increased survival in cells treated with epirubicin, a DNA-damaging drug. However, it did not alter the rate of cell proliferation. Weboncogenic role of Shp2 was reported, such as in breast cancer (Zhou and Agazie 2008), gastric cancer (Matozaki et al. 2009; Kim et al. 2010), and lung cancer (Grinnell et al. 2010). However, the role of wild-type Shp2 in cancer progression might be more tissue specific as its tumor suppressor role was reported in liver cancer cell lines
WebApr 18, 2024 · Despite available treatments, breast cancer is the leading cause of cancer-related death. Knowing that the tyrosine phosphatase SHP2 is a regulator in tumorigenesis, developing inhibitors of SHP2 ... WebJan 4, 2016 · The upregulated expression of SHP2 in breast cancer, including BTBC [ 18, 19 ], and its positive role in breast cancer cell transformation [ 20, 21] provide supporting evidence for this possibility. SHP2 is a cytoplasmic protein with two SH2 domains in the N terminal region and a phosphotyrosyl phosphatase domain in the C-terminal region [ 15 ].
WebMar 5, 2012 · The protein phosphatase SHP2 plays a fundamental role in breast cancer proliferation, invasion, and metastasis. When the scientists depleted SHP2 from breast cancer cells with a small hairpin RNA, it decreased proliferation and invasiveness in 3D cultures, blocked tumor growth, and reduced metastasis. What is more, they showed in a …
WebJul 30, 2024 · PTPN11/SHP2 is widely believed to be an oncoprotein, although it’s possible tumor-suppressor role is also reported. Our analysis of breast cancer metadata shows, PTPN11/SHP2 copy number loss in luminal A subtype is correlated to poor disease-specific survival and late-stage cancer at diagnosis. google chromecast from pc to tv doesn\u0027t workWebn/a Ensembl ENSG00000207656 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 7: 93.48 – 93.48 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 489 is a miRNA that in humans is encoded by the MIR489 gene. Function This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by … chicago blackhawks toddler jerseyWebJun 23, 2024 · Treatment of metastasis remains a clinical challenge and the majority of breast cancer-related deaths are the result of drug-resistant metastases. The protein tyrosine phosphatase SHP2 encoded by the proto-oncogene PTPN11 promotes breast cancer progression. Inhibition of SHP2 has been shown to decrease metastases … chicago blackhawks tickets tonightWebApr 1, 2024 · The phosphatase SHP2, which plays a crucial role in mediating signal transduction between receptor tyrosine kinases and both the PI3K and MAPK pathways, is a potential target for combination treatment. Methods We tested combinations of PI3K and SHP2 inhibitors in several experimental breast cancer models that are resistant to PI3K … google chromecast home app for windows 10WebOct 11, 2024 · Yang et al. reported SHP2 degraders, and an analog of TNO155 (IC 50 = 11 nM) was chosen as a potent SHP2 binder and conjugated with thalidomide . One of the heterobifunctional molecules, ZB-S-29 ( Figure 8 d), has been identified to be more effective in inhibiting cell growth of MV4-11 cells than SHP099 via effective degradation of SHP2 … chicago blackhawks toddler apparelWebMar 5, 2012 · The protein phosphatase SHP2 plays a fundamental role in breast cancer proliferation, invasion, and metastasis. When the scientists depleted SHP2 from breast cancer cells with a small hairpin RNA, it decreased proliferation and invasiveness in 3D cultures, blocked tumor growth, and reduced metastasis. google chrome cast imagesWebIn this manner, the important position of Shp2 in breast cancer is established. Therefore, the function of this protein in gastric and lung cancers has been investigated 16,17. Shp2 may also play an important role in the progression of oral squamous cell carcinoma (OSCC) 18. google chromecast how to use