Myc and atf4
WebMechanistically, we identified ATF4 as a novel regulator which coordinates with N-Myc to directly activate ASCT2 expression. Of note, ASCT2 expression, which correlates with … Web21 aug. 2014 · Mechanistically, we identified ATF4 as a novel regulator which coordinates with N-Myc to directly activate ASCT2 expression. Of note, ASCT2 expression, which …
Myc and atf4
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Web13 nov. 2012 · MYC -transformed cells depend on both glutamate-oxaloacetate transaminase and glutamate dehydrogenase to maintain Gln homeostasis and suppress apoptosis. Consequently, either ATF4 agonists or glutaminolysis inhibitors potently induce apoptosis in vitro and inhibit tumor growth in vivo. Web13 mei 2024 · The high expression of MYC and BCAT2, but not that of BCAT1 and BCKDHA, correlated with poor overall cancer survival. Inhibiting the MYC function by 10058-F4, the BCAA uptake by NALA, and the BCATc activity by gabapentin led to concentration dependent reductions in the cell viability and proliferation of the DLBCL cells.
Web12 okt. 2015 · ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation. J Pathol 2015; 235 : 90–100. Article CAS … Web1 jul. 2024 · d, Overlap of MYC- and ATF4-binding genes (significance estimated by hypergeometric test of MYC and ATF4 bound genes in 8 h …
Web1 jan. 2015 · Mechanistically, we identified ATF4 as a novel regulator which coordinates with N‐Myc to directly activate ASCT2 expression. Of note, ASCT2 expression, which … Web12 okt. 2015 · Other recent data has shown that ASCT2 is not only regulated by ATF4, but also by N-Myc, 42, 43 adding to the well described role of c-Myc in transcriptionally regulating glutamine metabolism. 44 ...
Web26 dec. 2024 · Elevated EAAs, in turn, stimulate Myc mRNA translation, in part through attenuation of the GCN2-eIF2α-ATF4 amino acid stress response pathway, leading to …
Web图片来源：新浪财经 起因是7月1日，著名科学杂志《自然》的子刊《Nature Cell Biology》刊登了一篇论文，文中描述了一种臭名昭著而又让人束手无策的原癌基因——MYC和它的“好搭档”ATF4，如何被研究人员成功“拆散”、并且最让癌细胞终走向自我毁灭的过程。. MYC是一种早已明确的强大原癌基因 ... my spartan student loginWeb1 aug. 2024 · In this issue of Cancer Research, Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) … my spartan mower wont startWeb21 mei 2024 · Additionally, Erk can phosphorylate c-Myc, leading to its stabilization and activation. Mithramycin, ... However, whether they can modify transcription factors such as ATF4 or c-Myc that have been implicated in pro-death responses to neuronal ferroptosis in neurons is not established. Iron in Ferroptosis: ... the shish basingstokeWeb4 nov. 2024 · Schmidt et al. show that the translation initiation factor eIF2B5 regulates stress responses and MYC translation to prevent apoptosis, thereby presenting a targetable vulnerability in colorectal ... the shiseido groupWebNational Center for Biotechnology Information my sparrow songWeb1 jan. 2015 · A systemic glutamine influx analysis identifies that MYCN‐amplified neuroblastoma cells predominantly rely on activation of ASCT2 to maintain sufficient levels of glutamine essential for the TCA cycle anaplerosis, and elucidate a novel mechanism depicting how cell autonomous insults (MYCN amplification) and microenvironmental … the shishWeb8 feb. 2024 · In turn, elevated c-MYC supports ATF4 translational induction by enhancing the expression of the amino acid transporter SLC7A5, increasing the uptake of essential amino acids, and the subsequent maintenance of mTORC1 activity in asparagine-restricted melanoma cells. my sparx login