Nettet(B and C) In vivo effect of ER stress on Purkinje neurons in wild-type (WT) and heterozygous IP 3 R1 knockout mice (IP3R1+/−).Representative hematoxylin and eosin (HE)-stained (B) and α-calbindin-stained (C) cerebellum sections from WT and IP3R1+/− mice sacrificed 2 days after injection of Tun (1 μg/g) or control phosphate-buffered … NettetIP3R1 localizes to dendrites and is thought to be locally translated in response to synaptic activity. Iijima et al. (2005) showed that the 3-prime UTR of mouse Ip3r1 was required …
Maintenance of normal blood pressure is dependent on IP3R1
NettetHuman diseases caused by Itpr1 mutations. The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in … NettetIsotype: Mouse IgG2a Immunogen: Human IP3R-3 aa. 22-230 Application: Western blot (Routinely Tested), Immunofluorescence, Immunoprecipitation (Tested During … indian hereditary class crossword
ITPR1-specific antibody (19962-1-AP) Proteintech - ptglab
Nettet24. aug. 2024 · In this study, we utilized the Cdk5−/− mouse model and corresponding ex vivo MEFs to explore the mechanisms by which Cdk5 regulates intracellular Ca 2+ dynamics and Ca 2+ -mediated cell proliferation. We demonstrate that Cdk5 targets IP3R1 to control ER Ca 2+ release and [Ca 2+] cyt. Nettet9. jun. 2024 · This Tespa1-IP3R1 interaction is mediated by the F187 and F188 residues of Tespa1 and the amino-terminus of IP3R1. Tespa1-F187A/F188A mutant mice phenocopy Tespa1-deficient mice with impaired late ... Nettet1. jun. 2024 · Mouse atrial cardiomyocytes (HL-1 cells) and rats with T2DM were used as study models. ... The IP3R1–GRP75–VDAC1 complex mediates ERS–mitochondria-associated ER membranes (MAM)–mitochondrial oxidative stress and plays an important role in diabetic atrial remodeling. local weather 20769