site stats

High-affinity choline transporter 1

Web10 de jun. de 2005 · Maintenance of acetylcholine synthesis depends on the effective functioning of a high-affinity sodium-dependent choline transporter (CHT1). Recent studies have shown that this transporter is predominantly localized inside the cell, unlike other neurotransmitter transporters, suggesting that the trafficking of CHT1 to and from … Web3 de nov. de 2000 · Na +-dependent, high-affinity choline uptake in cholinergic neurons is the rate-limiting step in acetylcholine synthesis.Here we report the molecular cloning and …

Functional characterization of the human high‐affinity choline ...

WebFrom substrate specificity to promiscuity: hybrid ABC transporters for osmoprotectants WebDownload Zoom Anti-Choline Transporter Antibody, high affinity detects level of Choline Transporter & has been published & validated for use in IH & WB. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. SDS CoA References university of washington scholarships 2022 https://bneuh.net

The high-affinity choline transporter CHT1 is regulated by the ...

WebCHT1 is a member of the SLC5 family of solute transporters and is assigned to SLC5A7 ( 12. ). Its amino acid sequence has 20–25% homology with that of other members of this family ( 13. ). It has been assumed that all members of the family possess a common 13-transmembrane domain core ( 14. WebThe high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and… Expand 15 PDF Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice M. Bazalakova, J. Wright, +4 authors Web1 de out. de 2002 · High-affinity choline transporter 1. Gene. ChT. Status. UniProtKB reviewed (Swiss-Prot) Organism. Drosophila melanogaster ... Function. function. Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity). By ... recasting geralt

Choline transporter-like proteins 1 and 2 are newly identified …

Category:(PDF) From substrate specificity to promiscuity: hybrid ABC ...

Tags:High-affinity choline transporter 1

High-affinity choline transporter 1

The high-affinity choline transporter: a critical protein for ...

Web1 de mar. de 2001 · High affinity choline transporter 1 Alternative names Hemicholinium-3-sensitive choline transporter ( CHT) Solute carrier family 5 member 7 Gene names … WebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity …

High-affinity choline transporter 1

Did you know?

Web1 de out. de 2014 · The high-affinity choline transporter (CHT) is the rate-limiting determinant of acetylcholine (ACh) synthesis, yet the transporter remains a largely undeveloped target for the detection and… Expand 15 PDF Competitive inhibition of the high-affinity choline transporter by tetrahydropyrimidine anthelmintics. WebThe high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice Authors M H Bazalakova 1 , R D …

WebCHT1 protein is mainly found in intracellular organelles, such as endosomal compartments and synaptic vesicles. The presence of CHT1 at the plasma membrane is limited by … WebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high …

WebThe high-affinity choline transporter (CHT1), which is specifically expressed in cholinergic neurons, constitutes a rate-limiting step for acetylcholine synthesis. We have found that … Web1 de mai. de 1990 · It is demonstrated that these two affinity states of [3H]HC‐3 binding are totally interconvertible; addition of 0.1 mM ATP in the binding assay medium …

WebThe transporter protein was cloned and identified by Okuda and co-workers in 2000, and shown to exhibit high-affinity, sodium-dependent choline uptake ( Km ~2 μM) which …

Web8 de mar. de 2006 · The high-affinity choline transporter at the molecular level. Despite the fact that the high-affinity choline uptake system was described in the 1960s, the … university of washington rushuniversity of washington sat requirementsWeb31 de out. de 2000 · Here we report the molecular cloning and functional characterization of the human high-affinity choline transporter (hCHT1). The hCHT1 exhibits significant … recasting infantWeb29 de jan. de 2024 · Visceral hypersensitivity is a common feature of irritable bowel syndrome. Cholinergic system involves in the development of visceral hypersensitivity, and high-affinity choline transporter (CHT1) is of crucial importance in choline uptake system. However, involvement of CHT1 in visceral hypersensitivity remains unknown. recasting jason morganWebThe high-affinity choline transporter (CHT1) is responsible for uptake of choline from the synaptic cleft and supplying choline for acetylcholine synthesis. CHT1 internalization by clathrin-coated vesicles is proposed to represent a mechanism by which high-affinity choline uptake can be modulated. recasting home loanWebA choline uptake system with a high affinity for choline has long been assumed to be present in cholinergic neurons. Very recently, the molecular entity for the high-affinity … recasting in spanishWeb5 de mai. de 2024 · To examine the action of tetrahydropyrimidines on the nematode high-affinity choline transporter, we generated HEK293 cell lines stably expressing the high-affinity choline transporter from C. elegans (CHO-1), the ortholog of CHT1 (Okuda et al., 2000), and measured the high-affinity choline uptake activity in the presence of … recasting in teaching