Gspt1 molecular weight
WebFeb 1, 2024 · The Ceres scores for GSPT1 (CRISPR AVANA PUBLIC 20Q4) and CRBN protein expression (Proteomics) were accessed via the DepMap portal [19]. 2.12. ... Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene, 22 (40) (2003), pp. 6151-6159, 10.1038/sj.onc.1206641. View in Scopus Google Scholar WebProteintech's Rabbit Polyclonal eRF3a/GSPT1 antibody is validated in IF, WB, ELISA and shows reactivity with Human, Mouse, Rat samples. ... Calculated molecular weight: 68 aa, 4 kDa: Observed molecular weight: 80 kDa: GenBank accession number: BC009503: Gene symbol: GSPT1: Gene ID (NCBI) 2935: Conjugate: Unconjugated: Form: Liquid:
Gspt1 molecular weight
Did you know?
Web2 rows · Lane 1 : Anti-eRF3/GSPT1 antibody (ab126090) at 1/10000 dilution Lanes 2-4 : Anti-eRF3/GSPT1 ... WebAug 15, 2024 · We identified the domains of GSPT1 essential for cell survival and show that GSPT1 degradation leads to impaired translation termination, activation of the integrated …
WebMay 27, 2024 · Immunoblots for GSPT1 and IKZF1 proteins after the treatment with increasing concentrations of compounds 6 and 7 of: MV4-11 cells over 4 (A) and 24 h (B) and MHH-CALL-4 cells over 4 (C) and 24 h (D). WebDisclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation …
WebDec 1, 2024 · In this paradigm, small molecule degraders (either PROTAC or Molecular Glue (MG)) redirect the cell’s endogenous ubiquitin proteasome system and induce ubiquitination of the target protein or non-native substrate of an E3 ligase (neosubstrate) and its subsequent proteasomal degradation. ... Targeting GSPT1 by a novel cereblon E3 … WebAug 31, 2024 · Molecular docking studies with CRBN and GSPT1 followed by analogue synthesis identified a possible hydrogen bond interaction with the central pyrimidine ring as a molecular determinant of hit compounds’ …
WebAs a result, we identified 34f (TD-522), which exhibits strong anti-proliferative effects in both KG-1 (EC 50 = 0.5 nM) and TMD-8 (EC 50 = 5.2 nM) cell lines. Compound 34f effectively induced GSPT1 degradation with a DC 50 of 0.269 nM and Dmax of >95 % at 10 nM concentration in KG-1 cells.
WebOct 16, 2024 · Molecular docking studies with CRBN and GSPT1 followed by analogue synthesis identified a possible hydrogen bond interaction with the central pyrimidine ring as a molecular determinant of hit compounds' selectivity. canbury emergencies in primary care• Ozawa K, Murakami Y, Eki T, Yokoyama K, Soeda E, Hoshino S, Ui M, Hanaoka F (Mar 1992). "Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1". Somatic Cell and Molecular Genetics. 18 (2): 189–94. doi:10.1007/BF01233164. PMID 1574740. S2CID 12796634. • Kikuchi Y, Shimatake H, Kikuchi A (Apr 1988). "A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinas… fishing moon phase chartWebNov 10, 2024 · MRT-2359 is a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader in vitro and in vivo. MRT-2359 has been shown to induce tumor regression in multiple Myc-driven... canbury medical centre/dashboardWebCalculated molecular weight: 68 aa, 4 kDa: Observed molecular weight: 80-85 kDa: GenBank accession number: BC009503: Gene symbol: GSPT1: Gene ID (NCBI) 2935: … fishing moose lodgeWebWestern Blot. Theoretical MW. 94.8 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post … canbury gardens kingston pubWebPolyclonal Antibody for studying GSPT1 iso3. Cited in 12 publications. Validated for Western Blotting. Highly specific and rigorously validated in … fishing morecambeWebMG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1, with a DC 50 of 1.3 nM. MG … fishing moratorium