WebNov 1, 2002 · The coordinated function of cell-cycle genes is essential for cell division and differentiation in all eukaryotes, including higher plants 1., 2., 3..Among the various cell-cycle regulators, e2f (see Glossary) transcription factor and the retinoblastoma (rb) repressor are the key players; their deregulation causes tumour formation in mammals … WebAs major regulators of the cell cycle, apoptosis and differentiation, E2F transcription factors have been studied extensively in a broad range of organisms. The recent identification of atypical E2F family members further expands our structural, functional and molecular view of the cellular E2F activity. Unlike other family members, atypical E2Fs …
E2F transcription factors and digestive sy…
WebThe transcription factor E2F, the principal target of the tumor suppressor pRB, plays crucial roles in cell proliferation and tumor suppression. In almost all cancers, pRB function is disabled, and E2F activity is enhanced. To specifically target cancer cells, trials have been undertaken to suppress enhanced E2F activity to restrain cell proliferation or selectively … WebMar 12, 2024 · E2F transcription factors are key components of the RB/E2F pathway that, through the action of cyclin-dependent kinases, regulates cell cycle progression in both … business names registration act 2011 austlii
The E2F Family of Transcription Factors from - ScienceDirect
WebTranscriptional Regulation by the E2F Transcription Factors. E2F was originally identified as a cellular DNA binding activity that regulated expression of the viral E2 promoter.30,31 Since this seminal work, molecular analysis has revealed that the E2F activity is encoded by a family of DNA binding proteins, which includes transcriptional ... WebMar 22, 2002 · The E2F transcription factors are key components of the cyclin D/retinoblastoma/E2F pathway. Here we demonstrate thatArabidopsis thaliana contains … WebThe E2F transcription factors are key components of the cyclin D/retinoblastoma/E2F pathway. Here we demonstrate thatArabidopsis thaliana contains six functional AtE2F genes that are all expressed in cell suspension culture but show different patterns of expression during cell cycle progression. According to their structural and functional features, the six … business names with crystal