Creatinine clearance and tikosyn
Webrandomized patients to placebo or to doses of TIKOSYN 125 mcg, 250 mcg, 500 mcg, or in one study a comparator drug, given twice a day (these doses were lowered based on calculated creatinine clearance and, in one of the studies, for QT interval or QTc). All … WebIt is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 µg of dofetilide. ... half-life of dofetilide is roughly 10 hours; however, this varies based on many physiologic factors (most significantly …
Creatinine clearance and tikosyn
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WebThe dose of TIKOSYN must be individualized according to calculated creatinine clearance and QTc. (QT interval should be used if the heart rate is <60 beats per minute. There are no data on use of TIKOSYN when the heart rate is <50 beats per minute.) ... Calculated … This Medication Guide summarizes the most important information about TIKOS… The overall systemic clearance of dofetilide is decreased and plasma concentrati… TIKOSYN should not be used in patients with a baseline QT interval or QTc >44… WebThe dose of TIKOSYN must be individualized according to calculated creatinine clearance and QTc. (QT interval should be used if the heart rate is <60 beats per minute. There are no data on use of TIKOSYN when the heart rate is <50 beats per minute.) The usual …
WebMay 4, 2024 · Because elderly patients are more likely to have decreased renal function with a reduced creatinine clearance, care must be taken in dose selection (see DOSAGE AND ADMINISTRATION). Use In Women Female patients constituted 32% of the patients in the placebo-controlled trials of TIKOSYN.
WebTIKOSYN can cause serious ventricular arrhythmias, primarily Torsade de Pointes, which is associated with QT interval prolongation and is directly related to the plasma concentration of TIKOSYN. Reduced creatinine clearance or certain drug interactions will increase TIKOSYN plasma concentration and increase risk for development of serious ... WebJan 6, 2024 · Trial Evidence. The FDA approval of dofetilide for AF was based on data extrapolated from the two DIAMOND trials. 18 In the DIAMOND-CHF trial, dofetilide was more effective in conversion (12% vs. 1%) and maintenance of SR (HR 0.35; 95% CI, 0.22-0.57; p < 0.001) compared with placebo in patients with CHF and severe LV dysfunction. …
WebTo minimize the risk of induced arrhythmia, patients initiated or re-initiated on TIKOSYN should be placed for a minimum of 3 days in a facility that can provide calculations of creatinine clearance, continuous electrocardiographic monitoring, and cardiac …
Webbody weight and creatinine clearance. Smoking or coronary artery disease do not affect the disposition of dofetilide.16 • DRUG INTERACTIONS Dofetilide has significant interactions with cer-tain drugs that interfere with either its hepatic metabolism or renal excretion (TABLE 2). It has no known effects on any laboratory tests. talksport presenters picturesWebJul 7, 2024 · By comparing the creatinine level in urine with the creatinine level in blood, the creatinine clearance test estimates the glomerular filtration rate (GFR). GFR is a measure of how well the kidneys are working, especially the kidneys' filtering units. … talksport powered by fansWebTo minimize the risk of induced arrhythmia, patients initiated or re-initiated on TIKOSYN should be placed for a minimum of 3 days in a facility that can provide calculations of creatinine clearance, continuous electrocardiographic monitoring, and cardiac resuscitation. ... Calculation of creatinine clearance and QTc for all patients must ... two june sevillaWebDofetilide is contraindicated in patients with severe renal impairment (calculated creatinine clearance <20 mL/min). The risk of QT interval prolongation, Torsade de Pointes, and ventricular arrhythmias is directly related to dofetilide plasma concentration. A reduced creatinine clearance will increase dofetilide plasma concentration. talksport radio app downloadWebTest Overview. Creatinine and creatinine clearance tests measure the level of the waste product creatinine (say "kree-AT-uh-neen") in your blood and urine. These tests tell how well your kidneys are working. Another substance, creatine (say "KREE-uh-teen"), is … two jumper cables walk into a barWebThe overall systemic clearance of dofetilide is decreased and plasma concentration increased with decreasing creatinine clearance. The dose of TIKOSYN must be adjusted based on creatinine clearance (see … talksport predictor footballWebCalculated Creatinine Clearance TIKOSYN Dose >60 mL/min 500 mcg twice daily 40 – 60 mL/min 250 mcg twice daily 20 – <40 mL/min 125 mcg twice daily <20 mL/min Dofetilide is contraindicated in these patients Step 4. Administer the adjusted TIKOSYN dose and begin continuous ECG monitoring. Step 5. At 2–3 hours after administering the first ... two junglers