WebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of … WebJan 3, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and …
Cisplatin nephrotoxicity: new insights and therapeutic …
WebSep 1, 2024 · The mechanism of cisplatin-induced nephrotoxicity (CIN) has long been investigated in order to develop preventive/therapeutic drugs. Ferroptosis is a newly identified form of non-apoptotic regulated cell death induced by iron-mediated lipid peroxidation and is involved in the pathophysiology of various diseases. In this study, we … WebSep 1, 2024 · The mechanism of cisplatin-induced nephrotoxicity (CIN) has long been investigated in order to develop preventive/therapeutic drugs. Ferroptosis is a newly … jayco outback swan size
Direct impact of cisplatin on mitochondria induces ROS ... - Nature
WebMar 9, 2024 · The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to aggravate AKI induced by cisplatin. WebMay 22, 2024 · Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms iScience. 2024 May 22;23 (5):101054. doi: 10.1016/j.isci.2024.101054. … WebThe mechanisms of cisplatin-induced nephrotoxicity are complex and involve multiple pathways and molecules ( Figure 1) [ 92, 93 ]. The cellular pathways of cisplatin injury … jayco partridge ottawa